Endocrine Abstracts

Introduction: Weight loss is a key initial treatment strategy in obese women with polycistic ovary syndrome (PCOS) and improves insulin sensitivity and metabolic risk factors. In some women with PCOS it may reduce hyperandrogenism and restore menstrual function, ovulation and fertility. The aim of this study was to reveal clinical predictors of menstrual response to weight loss in overweight women with PCOS.Design: overweight unovulatory women with PCOS ...

Introduction: Calcium transport is regulated by active transcellular and passive paracellular pathways which are responsible for calcium (re)absorption in the intestine and kidney. The activity of passive transport is determined by the permeability of tight junction. In general, the permeability of tight junction is inversely proportional with the expression of tight junction genes. Claudin and occludin among the tight junction genes are concerned directly with permeability of...

Testosterone deficiency is common in men with type 2 diabetes (T2D) and cardiovascular diseases (CVD), such as atherosclerosis. Previous studies have shown that testosterone replacement improves several cardiovascular risk factors including insulin resistance, glycaemic control, cholesterol and inflammation. The mechanisms by which testosterone mediates these effects are unknown. LXR, a nuclear receptor also regulates these cardiovascular risk factors and the atheroprotective ...

Hyponatraemia is the most common electrolyte abnormality, encountered in up to 30% of inpatients. Inappropriate management can have serious implications for patients; including demyelinating disease, coma, and death.Methods: Patients (n=100) admitted to the medical admission unit of a district general hospital with a serum sodium (Na) <130 were selected for the study. All details including patient demographics, blood biochemistry, date of admi...

Introduction: Acromegaly and Waldenstrom’s macroglobulinaemia are two rare diseases (about 3–4 and 10 cases/million per year respectively), the association between them is even more infrequent, one case being reported in the available literature.Case report: We present the case of a 74-years-old female (I.I.) suffering with both diseases. In 1997 acromegaly diagnosed by dysmorphic syndrome, than in 2004 hormonal/imagistical investigations (GH a...

We report three patients who were referred for possible chronic fatigue syndrome and presented with a long standing history of a multitude of symptoms. Comprehensive investigations revealed a low IGF1 and subsequent insulin tolerance test (ITT) demonstrated growth-hormone (GH) deficiency with a normal MRI pituitary in each case. The first patient presented at the age of 34 years with lethargy, aches and difficulty concentrating. Biochemically the only abnormality in th]e basal...

Protein phosphatase 2A (PP2A) is a multimeric serine/threonine phosphatase which has multiple functions. However, the potential involvement of PP2A in insulin’s metabolic signaling pathway is presently unknown. Brain insulin resistant state is characterized by disturbances in transducing the signal from IR/IRS/AKT, changing feeding behaviour and body weight. We showed that diet induced obese rats (DIO) have a marked increase in PP2A protein expression in the hypothalamus....

Mitochondria oxidize food substrates to generate energy for cellular work and heat is variably generated depending on the degree of coupling of electron transport to oxidative phosphorylation (OXPHOS). It has been hypothesized that climatic pressures exerted selection for mitochondrial haplogroup in arctic populations for a lower coupling of mitochondrial respiration to ATP production in favor of heat production. In this study muscle mitochondrial function was studied in Inuit...

Ghrelin as well as leptin are involved into regulation of food intake, development of obesity, diabetes (DM I, DM II) and inflammation. However, in spite of many experiments, the correlation between their effects are not fully established. As a part of study dealing with the interaction of ghrelin and leptin in metabolic disorders the present study was carried out to assess the effect of statin, DMI, DMII on the ghrelin and leptin plasma levels in lean and obese piglets. Anima...

Objective: Albuminuria has been shown to predict cardiovascular disease in populations with diabetes mellitus. The aim of this study was to assess the mean pressure values and the circadian rhythm of blood pressure during its ambulatory monitoring in normotensive diabetic patients, dividing them according to the presence of microalbuminuria.Methods: The study group comprised of 77 type 2 diabetic patients. Their mean age was 56.5±6.7 years, and the ...